Margarita Mikhaylova, DO

Board Certified Neurologist

Board Certified Neurologist

Meet Dr. Margarita Mikhaylova

Dr. Margarita Mikhaylova is a board-certified neurologist specializing in clinical neurophysiology and epilepsy, with additional expertise in headache medicine and therapeutic Botox® for neurological conditions. 

She completed her Bachelor’s and Master’s degrees in Biology with a concentration in Biotechnology at the Macaulay Honors College at Hunter College, where she graduated as class salutatorian. She earned her medical degree from the New York Institute of Technology College of Osteopathic Medicine (NYITCOM) and went on to complete her medical internship at Mount Sinai Queens.

Dr. Mikhaylova trained in neurology at Northwell North Shore–LIJ, where she served as Chief Resident, followed by an advanced fellowship in clinical neurophysiology with a focus on EEG and epilepsy. She has presented research at the American Academy of Neurology and has been invited to teach neuroscience at the Tel-Aviv University Sackler School of Medicine.

Her clinical interests include epilepsy, headache medicine, and neuromuscular disorders, as well as neurophysiologic testing (EEG and EMG). She has published on the management of medication-overuse headache and is extensively trained in the use of Botox® for chronic migraine, cervical dystonia, TMJ dysfunction, and hyperhidrosis.

In addition to her conventional neurology training, Dr. Mikhaylova is certified in functional medicine and practices through a whole-person lens that honors the connection between the brain and the body. Her approach integrates mind–body medicine, nervous system regulation, gut and metabolic health, and lifestyle therapeutics. When appropriate, she incorporates evidence-based nutraceuticals and holistic interventions to support healing at the root level. She regularly  collaborates with a trusted network of acupuncturists, osteopathic manual practitioners, and nutritionists, allowing patients to access deeply coordinated, integrative care.

Education & Training

  • Medical School– New York College of Osteopathic Medicine (NYIT-COM)
  • Residency –  Neurology, Northwell North Shore–LIJ (Chief Resident)
  • Fellowship – Clinical Neurophysiology (EEG/Epilepsy), North Shore Hospital

Clinical Research & Trials

Alzheimer’s Disease
  • Phase 3 Randomized Study of Simufilam for Mild-to-Moderate Alzheimer’s (Cassava Sciences; NCT05026177)
  • Phase 3 Adaptive Study of NE3107 for Alzheimer’s Disease (BioVie Inc.; NCT04669028)
  • Phase 2a Study of CST-2032 and CST-107 for Cognition in Mild Cognitive Impairment or Dementia (Curasen Therapeutics; NCT05104463)
  • Double-Blind Study of NE3107 in Parkinson’s Disease (BioVie Inc.; NCT05357989)
  • Phase 2a Cognitive Study of CST-2032 and CST-107 (Curasen Therapeutics; NCT05104463)
  • Phase 2 Trial of ABP-450 (PrabotulinumtoxinA) for Migraine Prevention (AEON Biopharma)
  • Phase 2/3 Trial of Zavegepant for Migraine Prevention (Biohaven Pharmaceuticals)
  • Phase 4 Study of Rimegepant for Acute Migraine (Biohaven Pharmaceuticals)
  • RELIEV-CM2 Study of the Shiratronics Migraine Therapy System (Shiratronics Inc.)
  • SENSE-VM Device Study for Vestibular Migraine (Otolith Labs; NCT06267924)
  • Phase 3 Rimegepant Trial for Pediatric Acute Migraine (Biohaven Pharmaceuticals)
  • Phase 3 Open-Label Rimegepant Safety Study in Pediatric Migraine (Biohaven Pharmaceuticals)
  • Phase 3 Valbenazine Trial for Dyskinesia in Cerebral Palsy (Neurocrine Biosciences)
  • Post-Marketing Comparison of Dysport® vs. Botox® for Upper Limb Spasticity (Ipsen Pharma)
  • Open-Label Cenobamate Monotherapy Study in Partial-Onset Epilepsy (SK Life Sciences Inc.)

Profile Details

Board Certifications:

Neurology – American Board of Psychiatry and Neurology

Epilepsy – American Board of Psychiatry and Neurology

Institute of Functional Medicine Certified Practitioner©

Specialties:

Clinical Neurophysiology

Epilepsy

Headache Medicine (including Botox® therapy for chronic migraine, cervical dystonia, TMJ dysfunction, and hyperhidrosis)

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